Together we will beat cancer

Dr Len Lichtenfeld

Dr Len reflects on progress and remaining challenges in cancer

Dr Len Lichtenfeld is deputy chief medical officer for the American Cancer Society. We invited Len to share his thoughts about our shared challenge of beating cancer.

As well as giving his unique perspective on the US’s “war on cancer”, Dr Len writes about the similarities and differences between the US and UK in our approaches to preventing, detecting and treating the disease:

It has been a long slog since we started our war on cancer here in the United States in 1971.

At times I am not certain that this has been so much of a war as opposed to a series of skirmishes that occasionally have produced incredible moments of optimism. But there have been a fair share of frustrations as well along the way. Our science and our care have made significant progress, but sometimes we find ourselves asking, “What have you done for me lately?”

I think it is important to reflect on the progress that we have made on several fronts in detecting cancer earlier, treating it more effectively and providing quality of care for those who find themselves caught in the jaws of illness, especially for those whose journey has not been successful.

The screening dilemma

When I talk about the prevention and early detection of cancer I remind people of the state of affairs we found ourselves in back in the 1970s: we had precious little to offer in the way of early detection, save for the Pap smear in cervical cancer. We were convinced that if we only could find cancer earlier we would be able to save lives.

Mammography for breast cancer, screening for bowel cancer and PSA testing for the early detection of prostate cancer came along, and while research demonstrated that we could effectively find breast and colon cancer earlier and save lives, we weren’t quite as rigorous when it came to prostate cancer.

Patient consultation

Balancing the benefits and risks of screening is challenging

Fast forward 40 years or so, and we find ourselves on the horns of several dilemmas where we can find many cancers much earlier than before, and we can even find cancers we never anticipated or intended to look for, as is the case with incidental cancers that are found on CT scans.

But finding all of these cancers has left us with another dilemma, namely whether we are really helping all those people where the cancer may never have caused difficulty during their lives.

We are still not able for the most part to separate the more indolent cancers from those that are more aggressive. As we find more cancers, that has become an increasingly important distinction. For now, suffice to say – especially for prostate cancer – we are probably treating many more people with aggressive therapies that they really don’t need.

Countries around the globe in the developed world struggle with the dilemma. Here in the United States, screening for cancers is widely available and readily accepted as effective, even when the science raises serious and important questions about that effectiveness. As a result, many people are treated with expensive therapies that at best may not do them any good, and in fact may do harm.

Undoubtedly some people are helped, but we can’t say for certain who they are. And then there are the unfortunate folks whose disease develops quickly between screenings, or when the cancer may be so aggressive that even detection on screening doesn’t do a whole lot to alter the course.

Treatment arms race

On another front in this “war” we have a treatment arms race under way in the US and that is the increasing cost of techniques, procedures and medications. For example, proton beam machines designed to deliver very high doses of radiation in very precise dimensions are flourishing.

Forget that there is no real evidence – except in very specific instances where cancers may impinge on vital structures or in certain pediatric cancers – that they really make a difference. Robotic surgical devices have captured the eye of the public who believe that they are magical and “gee whiz,” yet the number of proven advantages are limited.

The United Kingdom has generally adopted a more restrained approach to cancer care. There is at least some level of review, based on measures of effectiveness, which limits proliferation of these devices. The decisions that are made are not universally accepted, but that is the trade-off in a national health scheme that provides more care to more people at lower cost. It would lead to a revolt in the United States.

There is no doubt that we folks on this side of the ocean are going to have to face a harsh reality that we cannot continue on our current path. It is not sustainable. The UK is going to have to decide how to get more technology and more expensive drugs to people in the face of limited budgets, and the reality that newer treatments are potentially effective while being incredibly more expensive than the drugs they replace.

An image of chemotherapy drugs

New targeted drugs can be expensive

The targeted therapies that we have developed, and the targeted therapies we will develop, as a result of our increasing knowledge of what makes a cancer cell a cancer cell may well be a Godsend. They may turn some cancers from killers to chronic diseases, much as has happened with chronic myelogenous leukaemia, where imatinib overnight changed the face of a very bad situation. But they are proving to be very, very expensive.

No matter which system of health care we live in – the fee-for-service system in the United States where everyone has to find the funds to pay for their share of treatments, or the more global care offered by the National Health Service in the UK – we are going to have to figure out how to pay for it. Progress is real, but it is incredibly expensive.

Ordinary people – and that includes almost all of us in both countries – can’t afford this stuff.

The value question

So that brings us to the basic question of what we value in health care and how we pay for it.

At one end of the spectrum, patients and families in the United States want access to the treatments we desire when we believe we need them. At the other end of the spectrum, the UK has made the decision to cover everyone, but you want the system to work better than it does.

Neither world is perfect.

The value question goes one step further when it comes to comparing the two systems. Here in the US, politicians, doctors and people in this country are constantly telling us how we have the best health care in the world.

Never mind that that claim is hard to support: we spend much more money per capita than anywhere else in the world, while our longevity – the length of our years – doesn’t come anywhere close to what other developed countries experience. We have tens of millions of people without health insurance, and millions more without adequate insurance to pay for the care they need, especially if they develop cancer.

While it is true that in the US we can provide people with lots of care with lots of advanced technologies if they become sick, we don’t do a decent job of preventing them from getting sick in the first place and we certainly don’t provide everyone with access to basic, high-quality, high-value care when they do get sick.

Image of pound coins

What do we mean by value in cancer care?

And then there are the folks who tell us how much better the results of treatment are here in the United States for cancer compared to the UK. The reality is that the differences can be less than perceived.

How one uses and reports statistics – such as how long someone survives after a cancer diagnosis as to opposed measuring the actual numbers of deaths per 100,000 people – can paint very different pictures.

Just because cancers are found earlier doesn’t mean that more people survive. They may just live longer with their disease but the death rates may be the same, not to mention that – as noted above – we may find many cancers through “early diagnosis” that would never have caused harm or death.

A recent article in a major health care journal proclaimed that people in the United States lived longer with their cancer than their unfortunate counterparts in the UK, thus justifying the loads of money we spend on cancer care. A couple of years ago one of our presidential candidates who has prostate cancer proclaimed that the poor men with prostate cancer in the UK don’t live long because they don’t get screened, and they don’t get the high-tech care we offer here.

The point was made to underline the failings of national health insurance compared to the excellent care here in the United States. It was wrong. It quietly went away as an issue.

What these folks have missed is that we probably find a lot more cancers here than you do there. That’s because we screen a lot more folks than you do there. But it is not so clear that you fare worse. Your cancer patient population probably represents the tip of the iceberg above water, while we are finding many cases below the water line who appear to live longer but really don’t. Their disease is simply found earlier.

And I would find it hard to say that people who get expert cancer care in the UK get inferior treatment from inferior doctors than those people would get in the United States. They may not get as much care, and it may not be as fancy. But I suspect your doctors are every bit as diligent as those in the United States. That has been the case for decades and I don’t think that has changed recently.

Hard decisions

So both our countries struggle with our realities, our fiscal constraints, our societal perceptions, and the limitations that both systems bring to the table. We share the same knowledge about cancer care, but we make different value judgements. And in the end I suspect there isn’t much difference.

(I am certain I will hear from those who disagree, which is fine with me. But always remember it is important to support perceptions with facts, and sometimes facts can be manipulated to support one position or the other.)

What is immutable is the fact that both our countries are going to have to come to grips with some very difficult issues when it comes to providing high quality cancer care. Those decisions won’t be easy, whether it relates to how we prevent and detect cancer early, or what treatments we choose to offer, or when we decide more treatment is futile. The UK has a long history of paying attention to quality of life, pain management and hospice care. Our politicians call that “death panels”. You call it compassion.

As I look into my crystal ball, I suspect that over the next number of years we are going to become a lot more like you than most people can imagine or want to imagine. Whether that is “good” or “bad” will always be in the eyes of the beholder. But it is a change we have to consider.

There may be some in the UK who look to the US and our latest, cutting-edge technology, with a tinge of envy about what we do when it comes to providing health care (actually, more often “sick care”) here in the United States. The problem is we can’t afford to keep doing it.

Clearly, at some point in the not too distant future, we in the US are going to have to make some difficult decisions about how we use the limited resources available for health care and provide greater access to those in need. I suspect there are some lessons you have learned and decisions you have made in the UK that we could benefit from.

That, my friends, would be an interesting turn of events.


Martin Ledwick September 11, 2012

Hi Linsey,
I manage the helpline at Cancer Research UK. We have a team of nurses here who you can talk things over with if you think it would be helpful. You can call us on freephone 0808 800 4040 from 9 to 5 Monday to Friday. From your post it is a little hard to work out exactly what your consultant meant, but we may be able to get a better understanding if we have a conversation with you.

Please do give us a call if you think it might be helpful.

Martin Ledwick RN
Head Information Nurse
Cancer Research UK

linseymoore2012 September 9, 2012

I’m interesed in the different approaches for treating secondary breast cancer. I live in the UK and my oncologist is treating me one drug at a time. He said in the US it would be a combined approach, a kind of “blast it out” theory as opposed to the UK one of finding out which specific drug is working and focusing on quality of life. What’s your view on this difference?

Gregory Pawelski September 6, 2012

I first came across in 2003, the disparities in cancer care between the US and the UK in a clinical trial by Dr. Ian Cree, studying how well chemosensitivity assays predict response to chemotherapy in patients with persistent, refractory, or recurrent ovarian epithelial, peritoneal, or fallopian tube cancer. The results were highly suggestive of an effect due to the assay, and the most successful drug regimens used were nearly all developed using the assay. However, UK results in cancer are always lower than in the US for a variety of reasons. Part of this is probably lead time bias, but data on surgical debulking may be part of the explanation. Patients in the US get a whole lot more surgery along the way than in Europe. Even in the underpowered Cree, et al study, the use of his ATP assay changed treatment decisions in something like 90% of the cases, but the study was too small to show that the changed treatment decisions were to the benefit of the patient, in terms of long survival. The study allowed the physician’s choice arm to include Dr. Cree’s own drug combination as the trial accrued (BMC Cancer. 2003: 3:19).

This experience taught me to look at those disparities closer, particularly when it comes to the British National Institute for Clinical Excellence (NICE). Based on clinical trials, results showing no difference between single-agent platinums versus platinum/taxol (GOG Trial #132, ICON3, ICON4), NICE determined that platinum/taxol should no longer be considered as standard therapy, and that a range of therapies are equally acceptable (Lancet 2002;360:500-501, 505-515). In the US, where the administration of platinum/taxol had been much more profitable to the treating oncologist than single-agent platinum, there had been the dogged insistance that platinum/taxol remained standard, despite clear lack of support for this position, based on the entirety of the clinical trials literature. Platinum-taxol is not superior to single-agent carboplatin and single-agent cisplatin.

I wrote a paper “Who Needs Taxol?” One of the researchers listed in the foot notes of the paper (Carcinomatous Meningitis: Taxane-Induced) which found what is called “dissemination after taxane-based chemotherapy,” had told me that the study he finally published in the journal Oncology, was rejected by all other American & European cancer journals (Journal of Clinical Oncology, Cancer, Annals of Oncology, European Journal of Cancer, International Journal of Cancer) where it had been submitted. The journal were reluctant to publish such a scientific report, simply because taxanes (both taxol and taxotere) were at the time very intensively advertised in these journals. Why would the UK look to the US with a tinge of envy about what we do when it comes to providing cancer care? Yes, the problem is we can’t afford to keep doing this, while NICE is trying to do something about it.