“Crack teams” to solve cancer mysteries

May 29, 2008
A crack team, earlier

A crack team, earlier

If you have a problem, if no-one else can help, and if you can find them… maybe you can hire…

…well, unfortunately, the heroes of that infamous 1980s TV action show aren’t much good at molecular biology, and are unlikely to crack the biggest problems in cancer.

So Cancer Research UK has had to come up with a better plan.

Read the rest of this entry »


Two genetic variants reduce cancer-causing effects of alcohol

May 27, 2008

Alcohol causes cancerThe ways that our genes and our lifestyle choices interact to affect our risk of cancer is one of the most fascinating areas of research in cancer prevention. But it’s all still a bit of a grey area. So most health messages tend to be very broad and general – simply because the evidence they are based on comes from studies of large groups of genetically diverse people.

But this is starting to change, as studies get more sophisticated. For example, a new piece of research published this week in Nature Genetics identifies two rare versions of the genes ADH1B and ADH7 that can lessen the harmful effects of alcohol in causing cancer in people who carry them.

Read the rest of this entry »


Nano no-no? You cannot be serious…

May 22, 2008

A carbon fibre tennis racket“Nanotechnology” – technology on a microscopic scale – has been one of the scientific buzzwords bandied about most often in recent years.

Its potential applications cut across the whole of science and engineering – from making stronger, lighter tennis rackets to delivering cancer drugs – and scientists and engineers around the world are rushing to bring new products to market that exploit nano-scale substances and devices.

But the field has always had a whiff of controversy about it, notably with Prince Charles predicting, in a 2004 speech, that the world could be overrun by self-replicating ‘grey goo’ nanomachines.

Read the rest of this entry »


Striking a deal with ‘Big Pharma’

May 19, 2008

A little bottle of pillsIt’s an inescapable fact that drug development costs money. Current estimates suggest that its costs are spiralling towards US$1 billion for just one cancer drug to make the journey from a twinkle in a scientist’s eye to a treatment in the clinic.

But as well as being an expensive time for drug development, it’s also an exciting one. We are now witnessing a wave of ‘next-generation’ drugs, specifically designed to hit biological targets in cancer cells while leaving healthy tissues unharmed.

But given the costs of developing drugs, hard decisions need to be made. Pharmaceutical companies may develop many chemical compounds with interesting anti-cancer properties, but even the biggest don’t always have the resources to develop them all further. This means that potentially life-saving drugs end up stuck gathering dust on their shelves.

Read the rest of this entry »


A valuable ASSIST – getting teenagers to put each other off smoking

May 16, 2008

Cool kids can help their peers to avoid smokingPeer pressure is the bane of a parent’s life. Anyone who has children, or indeed works with them, knows how blithely they will ignore an adult’s instructions, only to jump out of a tree if their mates recommend it.

But a group of UK researchers have found a way to turn peer pressure to their advantage – by encouraging cool kids to put their friends off smoking.

Read the rest of this entry »